Jaypee Institute of Information Technology (JIIT) 2008 B.E test 3:metabolic networks - Question Paper
JAYPEE UNIVERSITY OF INFORMATION TECHNOLOGY TEST - III (NOVEMBER 200$)
B.TECH (SEMESTER I)
COURSECODE: 07B12 BH01 MAX MARKS: 30
COURSE NAME: METABOLIC NETWORKS
COURSE CREDIT. 4 MAX TIME: IHR 30 MIN
Ql) DiagrammaticaHy depict the fates of the carbon skeletons of all the amino-acids, Also list the amino acids which are glucogenic, ketogenic & both glucogenic and kctogenic. (5)
Q2) ft-oxidation of palmiloyl-CoA to 3cetyl*CoA involves various steps. Describe each step along with structures of each metabolite. (5)
Q3) Describe the following:
i) Urea cycle
ii) Ketone bodies
iii) Citric acid cycle (9) Q4) Answer the following questions briefly:
a) How is dUMP converted to dTMP? Discuss the role of dihydrofolatc reductase and its inhibitors in chemotherapy of cancer*? (2)
b) What are (he sources of carbon and nitrogen atoms in purine ring? (I)
c) How docs allopunnol provide relief to gout symptoms'. (I)
d) Wh3t is the correct sequence of appearance of intermediates in the degradation of adenosine (structure & name of the enzymes is not required)? (I)
Q5) Fill in the blanks:
i) The end-product of_catabolism goes on to be converted to methylmalonyl
CoA and malonyl-CoA.
ii) AMP is converted to ADP by_
iih The first committed step of IMP pathway is catalyzed by_
iv) Adcnyl succinate lyase catalyses the formation of AMP from adcnvlosuccinatc with elimination of (0 25 x 4)
- "?
Q6) How many ATP/GTP molecules are generated in the conversion of:
i) Succinate to fumarate
ii) Malatc to oxaloacetatc
iii) Pyruvate to acetyUCoA
iv) Pyruvate to oxaloacctatc
v) Oxaloocetate to phosphoenol pyruvate (5)
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| Earning: Approval pending. |
