Jaypee Institute of Information Technology (JIIT) 2008 B.E Test 1 : Comparative and Functional Genomics - Question Paper
Jaypee University of information Technlngy Waknaghat Test-1
Course Code: 07B61BT11E MM: 20
Course Title: Comparative & Functional Genomics Max. Time: Ihr Course Credits: 4-0-0
Note: Please be brief and to the point
Q.No.l What differentiates an eukaryote genome from a prokaryote genome? (2.0)
Q. No. 2. Why and how the model genomes are identified? What are model genomes for humans and why? (2.0)
Q. No. 3. What arc different levels of genome analysis? What information content do you get from each analysis level? (2.0)
Q. No. 4. Why DNA markers arc preferred over the traditional markers? Which molecular markers do you foresee with a practical potential in the future and whv?
Q. No. 5. How would you demonstrate reproducibility of RAPD markers? Can you convert a RAPD marker into a specific marker and how? (2.0)
Q. No. 6. A full) sequenced genome is handed over to you. How would jou proceed (o identify and develop simple sequence repeat (SSRs) markers from the genome? Which SSRs would you recommend for practical usage and why? (2.0)
Q. No. 7. How and why genetic map of a genome is required for constructing a physical map? (2.0)
Q. No. 8. Which one is technically better between AFLP vs RFLP and under what situations? (2.0)
Q. No. 9. Why positional gene cloning is still preferred in spite of being the most tedious gene cloning strategy? Can genomics information speed up the process of positional gene cloning and how? (2.0)
Q. No. 10. Why restriction maps for large genomes can not be developed through traditional restriction mapping? What strategy is suitable for developing whole genome restriction maps and why7? (2.0)
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