Jaypee Institute of Information Technology (JIIT) 2008 B.E Test 1 : Drug Design Techniques - Question Paper
JAYPEE UNIVERSITY OF INFORMATION TECHNOLOGY,
BSSSS WHEFBPCEOm'COURSE CODE: 07B62BI108 MAX. MARKS: 20
COURSE NAME: DRUG DESIGN TECHNIQUES
COURSE CREDIT: 4-00 = 4_MAX. TIME: 1 H._
Ql. Each question carrics 1 mark. (1 *3 = 3)
i. Why only agonists or antagonists arc designed against ccll receptor proteins while inhibitors are designed against enzymes?
ii. What is a lead molecule? Why is it assumed significance?
iii. Why docs chirality associate with drug candidates?
Q2. Each question carries 1.5 marks (1.5 * 2 3)
i. What is rational dnig design and discuss its advantages? Explain how bioinformatics tools will be used to reduce drug development period?
ii. Discuss the significance of various steps used in ligand preparation which are used in computational lead design?
Q3. Each question carries 2 marks. Answer any two (2*2 = 4)
i. Draw a schematic diagram for the disease cycle of malaria? Explain how do you find out vaccinc and drug targets from the above diagram? (0.5 + 1.5)
ii. How does small molecular database searching help in lead design? Discuss the significance of various criteria used in ZINC database construction? (0.5 +
1.5)
iii. Why does the understanding of target-ligand interactions play an important role in lead design? Discuss the limitations of electrostatic interaction calculations for above analysis?
Q4. Each question tarries 3 marks. (3*2*6)
i. Two conformations of two molecules will be provided in a datasheet. Find out cliques from both atoms? How do you determine pharmacophore from a set of moleculcs? (2.5 + 0.5)
ii. Discuss the dift'erences between direct and indirect drug design? Discuss different methodologies used in the above two processes'* Explain why both the methods arc generally used in drug design for any kind of disease?
Q5. Explain various steps involved in the design of pharmacophore for Dopamine Dj rcccptor antagonist? How docs the final outcomc relate to pharmacophorc definition? (3.5+0.5) (4 Marks)
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