Jaypee Institute of Information Technology (JIIT) 2008 B.E Test 1 : System Biology - Question Paper

JAYPEE UNIVERSITY OF INFORMATION TECHNOLOGY

WAKNAGHAT. SOLAN

TEST- 1 FEB 2008 SEMESTER VIII

Course Name: System Biology    Max Marks: 20

Course Code: 07B72BI401

Course Credit: 3    Max Time: IHr

Answer any five questions.

Ql. Explain the possible cause of drug side effects using system biology approach? Give schematic model of your explanations.    (4)

Q2. Programmed cell death is generally regulated by three input signals like TNF. EGF and Insulin. Explain the regulatory mechanism of cell survival and cell death based on above three inputs using system biology approach? Give system model of your explanation?    (4)

Q3. What do you mean by reverse engineering cellular networks? Discuss the different issues and advantageous of reverse engineering cellular networks for discovering the possible networks of any physiological process.    (4)

Q4. What is the application of Boolean networks in system biology study? How a Boolean network is represented diagrammatically? Why Boolean networks are called deterministic and synchronous?    (4)

Q5. Find out whether any genes unequivocally determines gene A from the given data using mutual information index?    (4)

Input (time 'l') A B C D 0 0 0 0 0 I 1 0 1 1 1 0

Output (time t*T ) A < B C D o lo 0 0 1 1 1 I 0 I 1 I I 1

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Q6. What are dynamic Bayesian networks? How they are advantageous over Bayesian networks?

(4)

Attachment: jaypee-institute-of-information-technology--jiit--2008-b-e-21199-1.jpg

Earning:   Approval pending.