Uttar Pradesh Technical University (UPTU) 2007 B.Pharm Pharmaceutical Chemistry-VIII(Medicinal Chemistry-III) - Question Paper
Printed Pages : 2 PH - 484
(Following Paper ID and Roll No. to be filled in your Answer Book)
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PAPER ID : 5065
(SEM. VIII) EXAMINATION, 2006-07 PHARMACEUTICAL CHEMISTRY - VIII (MEDICINAL CHEMISTRY - III)
Time : 3 Hours] [Total Marks : 80
Note : Answer all the questions. All questions carry equal marks.
1 Attempt any two parts of the following : 10x2=20
(a) What are the different factors affecting QSAR study?
(b) Discuss the molecular modelling methodologies and their capabilities.
(c) Write on Hansch approach.
2 Answer any two of the following :
(a) Enumerate the drug cenjugation pathways and discuss glucuronic acid conjugation in detail.
(b) How are drugs met abolished by hydrolysis and reduction process.
(c) Write in short on prodrugs.
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(a) |
Classify anticoagulants and write the synthesis and |
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warfarin. | |
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(b) |
Discuss the SAR of calcium channel blockers |
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(1,4-Dihydropyridines) | |
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(c) |
Give the synthesis, mode of action and uses of |
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pentolamine. | |
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(d) |
Give the synthesis, uses and mode of action of |
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propranolar | |
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(e) |
Write a short note on Iopanoic acid as Diagnostic |
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agent. |
Attempt any two part of the following :
(a) Classify antithyroid drugs and discuss the mode of action of carbimazole.
(b) Discuss the structure activity relationship and sulphony/ureas.
Give the synthesis of tolbutamide and nutforim.
(c) Write mode of action and clinical application of propyl thio uracil, write about insulin.
5 (a) Give the synthesis uses and mode of action of Lamivudine and Zalcitabine.
(b) What do you mean by prostaglandius. Give SAR of prostaglandiues.
V-5065] 2 [ 1300 ]
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Attachment: |
| Earning: Approval pending. |
