Uttar Pradesh Technical University (UPTU) 2007 B.Pharm Biopharmaceutics & P'Kinetics(Pharmaceutics-VIII) - Question Paper

Printed Pages : 3    PH 362

(Following Paper ID and Roll No. to be filled in your Answer Book)

Roll No.

B. Pharm.

(SEM. VI) EXAMINATION, 2006-07 BIOPHARMACEUTICS & P'KINETICS (PHARMACEUTICS - VIII)

Time : 3 Hours]    [Total Marks : 80

Note : (1) Attempt all the questions.

(2)    All questions carry equal marks.

(3)    Be precise in your answer.

1 (a) Define the terms    1x4=4

(i)    Biopharmaceutics

(ii)    Drug absorption

(iii)    Drug distribution

(iv)    Pharmaco kinetics

(b) What are the various mechanisms of drug 8 absorption? Discuss the mechanism of passive diffusion.

OR

(b)    Discuss psysicochemical factors affecting    8 absorption of drug.

(c)    Write a note on plasmaprotein landing of 4 a drug.

2    Attempt any two :    8x2

(a)    What is plasma drug concentration time profile. Discuss the pharmacokinetic parameters which can be determined from such a profile.

(b)    What are pharmacokinetic models? What is the importance of developing such models?

(c)    Discuss zero order and first order absorption rate constants.

3    Answer any two :    8x2=16

(a)    Discuss one compartment open model for i.v. infusion.

(b)    Discuss the terms:

(i)    Apparent vol. of distribution

(ii)    Elimination rate const.

(c)    Discuss the criteria for obtaining urinary excretion data. Discuss its advantages and disadvantages in assessment of pharmacokinetic parameters.

4    Write short notes on (any four) :    4x4=16

(a)    Dosage legumen

(b)    Adjustment of dose in renal diseases.

(c)    Importance of drug interactions in drug therapy.

(d)    Loading and maintenance dose.

(e)    Therapeutic drug monaloug

5 Answer any four :    4x4=16

(a)    Define bioavailability. Discuss the objectives of bioavailability studies.

(b)    Discuss briefly the methods used for measurement of bioavailability.

(c)    Define the terms - Chemical equivalence, pharmaceutical equivalence, bioequivalence, and therapeutic equivalance.

(d)    Give advantages and disadvantages of Latin square cross over design.

(e)    Enumerate the factors affecting bioavailability of a drug from its dosage form.

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Attachment: uttar-pradesh-technical-university--uptu--2007-b-pharm-20228-1.pdf

Earning:   Approval pending.