Uttar Pradesh Technical University (UPTU) 2006 B.Pharm PHARMACEUTICAL CHEMISTRY - VIII (MEDICINAL CHEMISTRY - III) - Question Paper

Time:3Hours
[Total Marks : 80
Note : Attempt all ques.. All ques. are of equal value.

1. ans any 2 of the subsequent
marks[10x2]
(a) What is direct and indirect drug design ? explain their limitation of any.

(b) explain the various factors which are taken into consideration for drug design.

(c) What do you understand by the term geometric optimisation ?

2. ans any 2 of the subsequent
marks[10x2]
(a) discuss the importance of drug metabolism.

(b) provide the structures chemical name and the mode of action of frusemide and triamterene.

(c) Classify diuretics with examples. Narrate the importance of diuretics.

3. ans any 4 ques.
marks[5x4]
(a) Write a short note on antianginals.

(b) What is use of tolbutamide ? provide its structure and synthesis.

(c) provide the structure mode of action and synthesis of clofibrate.

(d) Write a note on importance of warfarin.

(e) Classify antihypertensive with examples.

4. ans any 4 ques.
marks[5x4]
(a) explain the mode of action of carbianazole with importance.

(b) provide the structure, mode of action and synthesis of amantadine.

(c) Write a note on importance of prostaglandius

(d) Disucss the importance of zalcitabine with its mechanism of action.

(e) Write a note on insulin.

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Earning:   Approval pending.