Uttar Pradesh Technical University (UPTU) 2008 B.Pharm Pharmaceutical Analysis-II - Question Paper

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PHAR-244-May 2008-Pharmaceutical Analysis-II

MAX MARKS 80

see the Attachment

Printed Pages : 2 PHAR - 244

(Following Paper ID and Roll No. to be filled in your Answer Book)

PAPER ID : 5107

(SEM. IV) EXAMINATION, 2006-07 PHARMACEUTICAL ANALYSIS - II

Time : 3 Hours] [Total Marks : 80

Note : (1) Attempt all the questions.

(2) All questions carry equal marks.

1 Answer any two of the following : 8+8=16

(a) TLC

(b) Packing and charging of column in column chromatography

(c) Descending paper chromatography.

2 Write any two of the following : 16

a. Importance and applications of HPLC

b. Working of G.L.

c. Thermal conductivity detector.

3 Give the basic principle, instrumentation and 8+8 applications of potentiometry or conductometry.

M

a) Give the preparation and estimation of

sodium methoxide solution.

b) Discuss theory of complexometry titration and indicators used in complexometry.

c) Estimation of calcium and magnesium in a mixture.

8+8

5 Answer any two of the following :

a) 800 mg of chloramphenicol powder was completely reduced with Zn + HC1 acid. The solution was filtered and then 10 ml. conc HC1 was added. This solution was tiltrated against

0.09810 M sodium nitrite using potentiometer for end point. The volume of 0.09810 M NaN0₂ solution used was 20.25 ml. Find out the percentage of chloramphenicol Mol. wt. of chloramphenicol is 323. Give the theory behind it.

b) 0.2128 gm. of an organic compound was digested using cone. H₂S0₄ & CuS0₄. This solution was subjected to Kjeldahl method of estimating of nitrogen. The volume of 0.08929N HC1 consumed to neutralize liberated ammonia was found to be 6.5 ml. Find out the percentage of nitrogen in the sample. Give the theory of nitrogen estimation by Kjeldahl method.

c) How will you estimate ethanol in galenicals in the presence of volatile components, steam volatilized fatty acids.

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