Uttar Pradesh Technical University (UPTU) 2010 B.Pharm Pharmaceutical Chemistry-VI (Medicinal Chemistry-II) - Question Paper

B. Pharm (UPTU)
Sixth Semester exam (Year 2009-2010)
Pharmaceutical Chemistry-VI (Medicinal Chemistry-II)

Time: three Hours Total Marks: 80

Note: Attempt all 5 ques..

1) Answer any 2 of the following: (2×8=16)
a) Explain the theory of Lock-key approach of drug design with suitable example.
b) What do you mean by QSAR analysis? Outline the biological parameters used in QSAR analysis.
c) Write notes on:
i) Ligand-receptor interactions
ii) Energy minimization

2) Write notes on any 4 of the following: (4×4=16)
a) Natural cardiotonics
b) Synthesis of nifedipine
c) Pharmacological classification of antiarrythmics
d) Medicinal uses of calcium channel blockers
e) Oral anticoagulants
f) Lipid lowering agents

3) Attempt any 2 of the following: (2×8=16)
a) Classify H-1 receptor antagonists. provide the synthesis of Diphenhydramine.
b) Describe the synthesis, mode of action and medicinal uses of ranitidine.
c) Write notes on:
i) Pyrimidine antagonists
ii) Synthesis of chlorambucil

4) Answer any 2 of the following: (2×8=16)
a) Discuss the SAR of Propionic acid derivatives of NSAIDS.
b) Explain the mode of action of sulpha drugs and explain their chemotherapeutic applications.
c) Outline the synthesis and uses of Nalidixic acid and Meferamic acid.

5) Answer any 2 of the following: (2×8=16)
a) What are diagnostic aids? provide the synthesis and uses of Iopanoic acid.
b) Give the Pharmacological classification of diuretics. Write the synthesis and uses of acetazolamide.
c) Write an account on " aldosterone antagonists".

Earning:   Approval pending.