Uttar Pradesh Technical University (UPTU) 2010 B.Pharm Pharmaceutical Chemistry-II (Organic Pharm Chemistry-I)00 - Question Paper

B. Pharm (UPTU)
Second Semester Examination, 2009-10
Pharmaceutical Chemistry-II
(Organic Pharm Chemistry-I)

Time: three Hours Total Marks: 80
Note: Attempt All parts.

Section-A
Attempt All ques. in this part. (16×1=16)
1) Delocalization of electrons occurs in a pi bond. (True/False)

2) Cis and Trans isomers are denoted by:
a) R and S
b) Z and E
c) D and L
d) ? and ?

3) The optical rotation shown by a substance in a solution of concentration 1gm/ml through a 1dm tube is known as ______.

4) Tertiary aliphatic halides undergo substitution by _____ mechanism.

5) Conformations are stereoisomers. (True/False)

6) The nature of alkynes is:
a) Neutral
b) Basic
c) Acidic
d) Amphoteric

7) 4n + two pi electron rule for aromaticity is known as:
a) Saytzeff rule
b) Huckel rule
c) Dewar's rule
d) Baeyer's rule

8) Halogens are deactivating and o, p-directing in Electrophilic Aromatic Substitution. (True/False)

9) Acidity of phenols is due to the stability of the ____ ion.

10) A reagent capable of yielding a carbanion is:
a) Schiff reagent
b) Fehling reagent
c) Grignard reagent
d) Baeyer reagent

11) The dehydration of _____ acids provide a lactone ring.

12) The mixing and re-distribution of electrons and orbitals is known as _____.

13) The full form of IUPAC is:
a) International Union of Pharmaceutical and Applied Chemists.
b) Indian Union of Pure and Applied Chemists.
c) International Union of Pure and Applied Chemistry.
d) Indian Union of Pharmaceutical and Applied Chemists.

14) Conjugated dienes provide 1, 2- and 1, 4- addition reactions. (True/False)

15) Arenes undergo Clemmensen and Wolf-Kishner reactions. (True/False)

16) The silver mirror test is provided by:
a) Aldehydes
b) Ketones
c) Aldehydes and Ketones
d) Neither aldehydes nor ketones

Section-B
Attempt any 6 ques. in this part. (6×4=24)
17) Discuss the physical and chemical properties of enantiomers and diastereomers.

18) Compare and contrast covalent and electrovalent bonds.

19) Describe the mechanism of substitution in alkanes.

20) Explain the basicity of aliphatic and aromatic amines.

21) Compare the properties and applications of Grignard reagent to Organolithium reagent.

22) Explain Inductive effect and Resonance effect with examples.

23) Write a note on alcohols as acids and bases.

24) Give the IUPAC names of:
a) Chloral
b) m-Xylene
c) Chloroacetyl chloride
d) DDT

Section-C
Attempt any 4 ques. in this part. (4×10=40)
25) What is optical activity and how is it measured? discuss the method of specification of configuration of compounds with 1 or more chiral centers. (10)

26) Discuss the different mechanisms of elimination reactions. (10)

27) Establish the cyclic structure of benzene. define orientation in Electrophilic Aromatic Substitution. (10)

28) Give the mechanism of the subsequent reactions (any Four): (4×2.5=10)
a) Nucleophilic Aromatic Substitution by elimination-addition.
b) Reimer-Tiemann reaction.
c) Anti-Markownikov addition in alkenes.
d) Hoffman's degradation.
e) Nucleophilic aliphatic substitution.

29) Explain the subsequent (any Four): (4×2.5=10)
a) Primary alcohols undergo oxidation whereas tertiary alcohols do not.
b) Chloroacetic acid is a stronger acid than acetic acid.
c) The more substituted the alkene, the faster it is formed.
d) Carbonyl compounds undergo nucleophilic addition.
e) Meso compounds are optically inactive.

Earning:   Approval pending.