Uttar Pradesh Technical University (UPTU) 2009 B.Pharm Pharmaceutical Chemistry-III - Question Paper

B. Pharm (UPTU)
Third Semester Theory Examination, 2009-10
Pharmaceutical Chemistry-III

Time: three Hours Total Marks: 80

Note: 1) Attempt All ques..
2) All ques. carry equal marks.

1) Attempt any 4 of the following: (4?4=16)
a) Classify ?, ? – unsaturated carbonyl compounds and briefly explain their reactivity towards nucleophiles.
b) Give the mechanism of cycloaddition reaction.
c) Briefly explain the synthetic applications of compounds containing active methylene group.
d) Discuss the structure and aromaticity of anthracene and naphthalene.
e) Give the Haworth's phenanthrene synthesis.

2) Attempt any 4 of the following: (4?4=16)
a) Give the reaction of
i) Fiest Binary Furan synthesis.
ii) Knorr-Pyrrole synthesis.
iii) Outline the importance of 1,4-diketones in the construction of 5 membered heterocyclics.
iv) Give any 2 methods of preparation of Indole.
v) Discuss the reactivity of pyridine towards electrophilic aromatic substitution reaction.
vi) Give structure, chemical name and properties of Benzimidazole.

3) Attempt any 2 of the following: (8?2=16)
a) Describe the reaction, mechanism and synthetic applications of Diels-Alder reaction.
b) Give the reaction and step-wise mechanism of a naming reaction used to prepare ?-hydroxy ester.
c) Write an account on:
i) Beckmann rearrangement
ii) Verley reduction.

4) Attempt any 2 of the following: (8?2=16)
a) Discuss the chair structures of all possible anomers of glucose.
b) Define with an example:
i) Glycosidic linkage
ii) Furanoside
iii) L-sugars
iv) Epimerization.
c) Discuss the structure of sucrose and lactose and provide their specific identification tests.

5) Attempt any 4 of the following: (4?4=16)
a) What is end-group analysis? discuss with examples.
b) Write the structure and importance of
i) Guanosine triphosphate
ii) Thymidine monophosphate.

c) Write notes on:
i) Glycoproteins
ii) Basic amino acids.

d) Define and discuss
i) Free radical polymerization
ii) Saponification value.

e) Write a note on structure of DNA.

Earning:   Approval pending.