Uttar Pradesh Technical University (UPTU) 2009 B.Pharm Pharmacology-I - Question Paper

Paper ID: 5035
B. Pharm (UPTU)
Fifth Semester Theory Examination, 2009-10
Pharmacology-I

Time: three Hours Total Marks: 80

Note: 1) ans All ques..
2) All ques. carry equal marks.

1) Answer any 2 of the following: (8×2)
a) Define subsequent terms with suitable example:
i) Receptor
ii) Agonist
iii) Antagonist
iv) Idiosyncrasy.
b) Discuss competitive and non-competitive inhibition mechanism of drug action.
c) Write brief note on Synergism and Drug efficacy.

2) Answer any 2 of the following: (8×2)
a) Explain subsequent terms:
i) Clearance
ii) Loading dose
iii) Therapeutic index
iv) Maintenance dose.
b) Discuss the process of discovery and development of new drug.
c) Write note on Bio-assay of drugs in detail.

3) Answer any 2 of the following: (8×2)
a) Discuss the pharmacological basis for the use of:
i) Physostigmine in myasthenia gravis
ii) Atropine in peptic ulcer.
b) Classify sympathomimetic drugs. Write the pharmacological action and use of ephedrine.
c) Enlist the comparative effects of adrenaline, nor adrenaline and isoprenaline.

4) Answer any 2 of the following: (8×2)
a) Give mechanism of action of:
i) Haloperidol
ii) Morphine
iii) Phenobarbitone
iv) Diazepam.
b) Classify general anesthetic drug and write mode of action of ketomine.
c) What is Parkinsonism? provide mode of action of levodopa and carbidopa.

5) Answer any 2 of the following: (8×2)
a) Discuss the mechanism of action and side effect of:
i) Succinylcholine
ii) Lignocain.
b) Classify skeletal muscle relexant and write mode of action of d-Tubocurarine.
c) Write note on use and technique of local anesthesia.

Earning:   Approval pending.