Uttar Pradesh Technical University (UPTU) 2009 B.Pharm Pharmaceutical Chemistry-IV (Bio Chemistry) - Question Paper

Paper ID: 5033
B. Pharm (UPTU)
Fifth Semester Theory Examination, 2009-10
Pharmaceutical Chemistry-IV (Bio Chemistry)

Time: three Hours Total Marks: 80

Note: 1) ans All ques..
2) All ques. carry equal marks.

1) Attempt any 2 of the following: (8×2)
a) Discuss the effects of temperature and pH on the kinetics of enzymatic reactions.
b) Explain the mode of action of coenzymes. provide structure and biochemical role of coenzymes derived from vitamin B2 and pantothenic acid.
c) Write an account on:
i) Allosteric inhibitors
ii) Transferases.

2) Attempt any 2 of the following: (8×2)
a) Give the complete pathway of glycogenolysis and explain the regulatory mechanisms of this pathway.
b) Explain gluconeogenesis. Show the entry points of glucogenic amino acids in this pathway.
c) Write notes on:
i) Significance of pentose phosphate pathway
ii) Citric acid cycle.

3) Explain any 4 of the following: (4×4)
a) ?-oxidation of even carbon containing fatty acid.
b) Structure of fatty acid synthase complex.
c) Role of NAD and FAD in respiratory chain.
d) Biosynthesis of ATP.
e) Essential fatty acids.

4) Attempt any 4 of the following: (4×4)
a) Biosynthesis of glutathione and its significance.
b) Catabolism of tyrosine.
c) Biochemical conversion of phenylalanine to epinephrine.
d) Double helical structure of DNA.
e) Steps in the DNA replication process.

5) Attempt any 2 of the following: (8×2)
a) Describe the lactose operon and tryptophan operon control mechanisms of gene expression (transcription) in prokaryotes.
b) Define genetic code and discuss the method of elucidation of genetic code.
c) Write notes on:
i) Formation of aminoacyl tRNA.
ii) Termination of protein synthesis.

Earning:   Approval pending.