Uttar Pradesh Technical University (UPTU) 2009 B.Pharm Pharmaceutical Chemistry-VI - Question Paper

B. Pharm (UPTU)
Seventh Semester Examination, 2009-10
Pharmaceutical Chemistry-VI

Time: three Hours Total Marks: 80

Note:
Attempt All ques..
All ques. carry equal marks.

1) Attempt any 2 of the following: (8×2=16)
a) Discuss the nomenclature and stereochemistry of naturally occurring steroids with examples.
b) Give the complete synthesis of stanazol and dexamethasone.
c) Write notes on:
i) Mode of action of steroids.
ii) Progestational agents.
2) Attempt any 2 of the following: (8×2=16)
a) Discuss the SAR of cephalosporins with respect to the structural changes at dihydrothiazole ring.
b) Write the synthesis of ethambutol and dapsone and explain their medicinal uses.
c) Write notes on:
i) ?-lactamase resistance penicillins.
ii) Mode of action of ?-lactam antibiotics.
3) Attempt any 2 of the following: (8×2=16)
a) Give the structure, chemical name, synthesis and mode of actions of tinidazole.
b) Write the chemical classification of anthelmintics with examples. provide the synthesis and mode of action of mebendazole.
c) Discuss briefly:
i) Imidazole containing antifungal agents.
ii) Mode of action of antiseptics and disinfectants.
4) Attempt any 2 of the following: (8×2=16)
a) Classify anti-HIV drugs. define the synthesis of any 2 anti-HIV drugs.
b) Write the structure, mode of action and therapeutic uses of lamivudine and carboprost.
c) Write notes on:
i) Role of pentose sugar or its derivatives in antiviral agents.
ii) Nomenclature of prostaglandins.
5) Attempt any 4 of the following: (4×4=16)
a) Explain thyrotoxicosis. provide the structure, chemical name and mode of action of any 2 drugs.
b) Describe briefly the structure of insulin.
c) Discuss the SAR of biguanidine based oral hypoglycaemic agents.
d) Explain the mode of action of glibenclamide and metformin.
e) Give the synthesis of tolbutamide and its medicinal uses.

Earning:   Approval pending.