Uttar Pradesh Technical University (UPTU) 2009 B.Pharm Pharmaceutics-VIII - Question Paper

B. Pharm (UPTU)
Seventh Semester Examination, 2009-10
Pharmaceutics-VIII

Time: three Hours Total Marks: 80

Note:
Attempt All ques..
All ques. carry equal marks.

1) Answer any 2 questions: (8×2=16)
a) Explain the role of pharmacokinetics parameters on development of formulation.
b) Discuss the effect of protein binding on bioavailability and quantity of distribution.
c) Write short notes on: (any two)
i) Active absorption
ii) Pinocytosis
iii) Physiological factors affecting absorption.
2) Answer any 4 questions: (8×2=16)
i) What is open compartment model? Classify various kinds of compartment models.
ii) Explain the method for determination of 1st order absorption rate constant by Wagner-Nelson method.
iii) Write short note on flip-flop method.
iv) Give different methods for measurement of plasma drug concentration.
v) Explain significance of non-compartment models in pharmacokinetics.
3) Answer any 2 questions: (8×2=16)
a) Explain determination of AUC, Cmax and Tmax from urinary/plasma data after drug administration by oral route using 1 compartment model.
b) Writs brief review on clinical pharmacokinetics.
c) Explain the method for computation of elimination rate constant using urinary drug elimination data for 1 compartment models.
4) Answer any 2 questions: (8×2=16)
i) What is drug-drug interactions, discuss with suitable example.
ii) Discuss dosage adjustment for patient with and without renal failure.
iii) Write note on dosage regimen.
5) ans any 2 questions: (8×2=16)
i) Differentiate relative bioavailability and absolute bioavailabity. discuss method for determination of bioavailability using urinary data.
ii) Give regulatory requirements for conduction of bioequivalence studies.
iii) Write short notes on: (any two)
a) Bioequivalence
b) Methods for determination of AUC
c) Federal regulation.

Earning:   Approval pending.