Baba Farid University of Health Sciences 2009 M.B.B.S [2nd Prof.] BF//11 Pharmacology - A - Question Paper

M.M. : 40 Time : three Hours
Note : Attempt all ques..
USE SEPARATE ans SHEET FOR every PART.

PART - I

1. Discuss the different factors affecting drug absorption with their clinical significance. [6]

2. Write short notes on:
a. Mechanism of actions of Proton pump inhibitors. [2]
b. Balanced Anaesthesia. [2]
c. Mechanism of action and adverse effects of Ketamine. [2]

3. Describe the pharmacological basis of the subsequent drugs with emphasis on their adverse effects:
a. Thiazides in the management of Hypertension. [2]
b. Nitroglycerine in Acute Angina attack. [2]
c. Donepezil in Alzheimers disease. [2]
d. Intravenous diazepam in Status epilepticus. [2]

PART – II

4. Enumerate different Antidepressant drugs. explain briefly regarding the mechanism of actions, adverse effects, drug interactions and any other uses of Fluoxetine. [6]

5. Discuss briefly on:
a. Role of Clopidogrel in ischemic heart disease. [2]
b. Drugs affecting Cardiovascular remodelling. [2]
c. Role of Amiodarone in Ventricular Arrhythmias. [2]
d. Role of Aliskiren in the treatment of Hypertension. [2]

6. Define & explain the subsequent (any THREE):
a. First Pass metabolism. [2]
b. Hit and Run drugs. [2]
c. 1st order kinetics of metabolism. [2]
d. Entero-hepatic circulation of drugs. [2]


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Earning:   Approval pending.