M.Sc-M.Sc Bio Chemistry 2nd Sem BCH - 270 : Bioenergetics and Metabolism(University of Pune, Pune-2013)

                             M.Sc. (Semester - II)

                             BIOCHEMISTRY

SEAT No. :

[Total No. of Pages : 2

BCH - 270 : Bioenergetics and Metabolism

(2008 & 2010 Pattern)

Time : 3 Hours]                                                                                               [Max. Marks : 80

Instructions to the candidates :

1) All questions are compulsory.

2) Figures to the right side indicate full marks.

3) Answers to the two sections should be written in separate answer books.

SECTION - I

Q1) Answer any five of the following :                                                                   [15]

“Although O2 is not involved in any step of TCA cycle yet the cycle is

aerobic”. Explain.

Why animals cannot effect the net conversion of lipid to carbohydrates

while plant or microorganism can? Illustrate your answer with enzyme- catalysed reactions involved in the net conversion of lipid to carbohydrate.

Write note on high energy compounds.

Differentiate between C3 and C4 pathways.

Tabulate the glycogen storage diseases with details of defective enzymes

and clinical features.

What is Pasteur effect?

Q2) Answer any three of the following :                                                                [15]

Outline the steps involved in pentose phosphate pathway.

Explain all the reactions involved in the conversion of lactic to glucose. Describe non-cyclic photophosphorylation and its significance.

Discuss chemiosmotic hypothesis of Peter mitchell in the formation of

ATP.

P.T.O.

Q3) Answer any two of the following :                                                                  [10]

Explain the role of hormones in the regulation of glycogenesis and

glycogenolysis.

Discuss the amphibolic role of TCA cycle.

Describe the reactions involved in the formation of Ascorbic acid from

glucose.

SECTION - II

Q4) Answer any five of the following :                                                                   [15]

Write note on phenylketonuria and Alkaptonuria.

Give the significance of decarboxylation of amino acids with suitable

examples.

What is the role of ribonucleotide reductase in our body?

What are ketone bodies? How are they formed?

List out the steps involved in the biosynthesis of polyamines.

How isb-alanine formed during pyrimidine catabolism?

Q5) Answer any three of the following :                                                                 [15]

Outline the cycle of reactions that converts Ammonia to Urea. Explainb-oxidation of palmitic acid with energetics. Discuss the biosynthesis of phenylalanine.

Elaborate on the regulation of biosynthesis of purine and pyrimidine

nucleotides.

Q6) Answer any two of the following :                                                                   [10]

a)       How are triglycerides prepared in our body.

b)       Explain the role of CDP in phospholipid biosynthesis.

c)       Describe the steps involved in formation of Uric acid.

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