M.Sc-M.Sc Medical Laboratory Technology 1st Year PAPER - II ENZYMOLOGY , METABOLISM AND INBORN ERRORS OF METABOLISM (Kerala University of Health Sciences-2013)
QP Code : 102383 Reg . No....................... .
First Year M.Sc. MLT Degree Examinations - February 2013
(Biochemistry)
PAPER - II ENZYMOLOGY , METABOLISM AND INBORN ERRORS OF METABOLISM
Time: 3 hrs. Max. marks : 100
• Answer all questions
• Draw diagrams wherever necessary
Essays: (10x10 = 100)
1. What is IUBMB .Classify enzymes according to the IUBMB classification with examples. Mention two differences between competitive and noncompetitive inhibition of enzymes. (2+ 6+2)
2. Discuss Embden -Meyerhof pathway ( aerobic and anaerobic) for Glycolysis. Add a note on its energetics. ( 8+2)
3. Explain in detail the metabolism of tyrosine . Add a note on any two important substances derived from Tyrosine. (8+2)
4. Short notes
• differential diagnosis of jaundice and its importance.
• Synthesis of creatine phosphate
(5+ 5)
5. Short notes:
• Acetyl Co A
• Ketogenesis and utilization of Ketone bodies.
6. Discuss briefly:
• Regulation of cholesterol synthesis (5+5)
• lipoprotein structure (5+5)
7. What is an inborn error of metabolism. Mention the enzyme defect, lab test and clinical signs to detect Von Gierke's disease, Niemann -Picks disease and Cutanea porphyria tarda . (1+3+3+3)
8. Schematically name and represent the components of electron transport chain. Add a note on mechanism of ox idative phosphorylation by chemiosmotic theory. ( 6+4)
9. What is a genetic mutation. Explain point and frame shift mutations . What is Down's syndrome and name any three tests for the screening of down's syndrome. (2+4+4)
10. Role of lipids in atheroscleros is and coronary heart disease .Add a note on serum lipid profile and their reference ranges. (6+4)
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| Earning: ₹ 7.05/- |
