Gujarat Technological University 2010 M.Pharm Drug Design and Discovery - Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharmacy Sem-II Examination July 2010
Seat No. Enrolment No.
Subject code: 920201 Subject Name: Drug Design and Discovery
Date: 07 /07 /2010 Time: 11.00 am - 02.00 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write in detail about the role of drug design in new drug discovery. 06
(c) Describe the main features of competitive, non-competitive and 05 irreversible inhibition of enzymes.
Q.2 (a) What is bioisosterism? How is it useful in the design of drugs? 06
(b) How has the penetration of blood brain barrier been made effective by 05 prodrug formation?
(c) Write a note on importance of stereochemistry in drug action. 05
Q.3 (a) What are the different QSAR methods used when biological activity is 10 expressed in qualitative term? Write in detail about any two methods.
(b) Write a note on recent developments in 3D QSAR. 06
Q.4 (a) What is an important tool of drug design to achieve de novo drug 10 discovery? Write in detail about it.
(b) Describe the Topliss Decision Tree Approach for prediction of 06 bioactivities
(a)
(b)
Q.5
10
06
10
06
10
06
Q. 6 (a)
Define molecular modeling. Briefly discuss the uses of molecular modeling.
How X-ray crystallographic data can be used to design bioactive compounds.
What is the principle that forms the basis of the quantum mechanical approach to molecular modeling? What are the advantages and disadvantages of it?
Write a note on importance of pharmacokinetics in drug discovery.
Q.7 (a) Explain SBDD with example, indicating utilization of structure derived from NMR and X-ray crystallography techniques.
(b) Write an account on ligand based drug design.
(b)
(c)
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