Gujarat Technological University 2012-2nd Sem M.Pharm - – –, drug design and discovery - Question Paper
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Univesity Name: Gujrat Technological University
Paper name:DRUG DESIGN AND DiscOVERY
Academic Year: 2012
Courses: M.Pharm 2nd semester exam
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Seat No.:__Enrolment No._
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM- SEM-II-EXAMINATION - JULY 2012 Subject code: 2920201 Date: 09/07/2012
Subject Name: DRUG DESIGN AND DISCOVERY Time: 10:30 am - 01:30 pm Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q 1.
a) Explain in detail concept of drug discovery. 06
b) What do you mean by drug design, explain its applications in drug discovery 05
c) What is 'LEAD' explain methods used for lead discovery. 05
Q 2.
a) Explain in detail the importance stereochemistry in drug design. 06
b) Write in detail importance of physicochemical parameters in biological activity. 05
c) Explain the following terms 05
i) Bio-isosterism
ii) Prodrug concept
Q 3.
a) What do you mean by QSAR, explain in detail Hanch LEFR model. 06
b) Write a note on QSAR parameters 05
c) What is Free Wilson analysis? Explain its significance 05
Q 4.
a) What do mean by variables and statistical analysis in QSAR 06
b) Explain following statistical analysis in detail 05
i)PLS ii) PCA iii) MFA iv) GFA
c) Write a note on 3-D QSAR. Write differences between 2-D QSAR and 3-D QSAR. 05
Q 5.
a) What do you mean by CADD, explain importance of molecular modeling? 06
b) What do you mean by following terms 05
i) Quantum mechanics
ii) Molecular mechanics
iii) Energy minimization
c) Explain in detail use of NMR and X-ray crystallography in CADD
Q 6.
a) What is structure based drug design and ligand based drug design. 06
b) What do you mean by docking study, explain different methods used in docking. 05
c) Write a note on theory of drug action. Explain in detail about agonist and antagonist. 05
Q 7.
a) What do you mean by virtual screening. Explain in detail about pharmacophore mapping. 06
b) Write importance of ADME in drug discovery 05
c) Write a note on following 05
i) COMFA
ii) COMSIA
iii) MSA
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