Tamil Nadu Dr MGR Medical University 2009 M.Pharm PHARMACEUTICAL CHEMISTRY - III – ADVANCED MEDICINAL CHEMISTRY - - Question Paper

MARCH -2009
[KU 320] Sub. Code: 2856
M.PHARM. DEGREE exam
(Regulations 2006)
Candidates admitted from 2006-2007 onwards
FIRST YEAR
Branch II – PHARMACEUTICAL CHEMISTRY
Paper III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262856
Time : 3 hours Maximum : 100 marks
ans All ques.
I. Essay ques. : (3 X 20 = 60)
1. a) explain different electronic parameters of QSAR studies.
b) Write a note on quantum mechanics in molecular modeling.
c) Add a note on Antineoplastic agents
2. a) explain the design and practical aspects of pro drugs.
b) elaborate the Enzyme inhibitors in basic research?
c) provide the methods of manufacture of Diphenhydramine.
3. a) explain the theoretical and practical aspects of Microbial transformation in
production of certain drugs.
b) Write a note on gastric acid inhibitors.
c) elaborate prostaglandins, provide their importance.
II. Write Short Notes : (8 X five = 40)
1. explain the role of chirality in therapeutic agents.
2. How do you manufacture sulphamethaxa zole.
3. Write short notes molecular mechanics.
4. Add a note on 3D QSAR approach
5. Write a note on immune response.
6. explain the inartio selectivity in drug distribution.
7. elaborate the forces involved in drug Receptor interactions?
8. Enumerate different approaches of drug design from lead molecule.

Earning:   Approval pending.