Tamil Nadu Dr MGR Medical University 2009 M.Pharm PHARMACEUTICAL CHEMISTRY - IV – NATURAL PRODUCTS OF MEDICINAL INTEREST - - Question Paper

MARCH -2009
[KU 321] Sub. Code: 2857
M.PHARM. DEGREE exam
(Regulations 2006)
Candidates admitted from 2006-2007 onwards
FIRST YEAR
Branch II – PHARMACEUTICAL CHEMISTRY
Paper IV – NATURAL PRODUCTS OF MEDICINAL INTEREST
Q.P. Code : 262857
Time : 3 hours Maximum : 100 marks
ans All ques.
I. Essay ques. : (3 X 20 = 60)
1. a) explain the Constitution of Morphine.
b) Briefly outline the counter current distribution for the separation of plant
constituents.
c) How do you determine methoxy, Hydroxylamide, N-methyl and
carboxyl groups current in alkaloids by chemical test.
2. a) explain the detailed applications of MASS Spectrometry for the structural
determination of natural products.
b) explain the nomenclature of steroid Nucleaus.
c) Write notes on structure of diosgenin.
3. a) provide an account of the chemistry of rutin.
b) Write short notes on cardiac glycosides.
c) explain the structural determination of xanthotoxin.
II. Write Short Notes : (8 X five = 40)
1. explain the mechanism of actions of penicillins.
2. Write a note on polypeptide antibiotics.
3. explain the effect of curcuma longa as an Antitumour drug.
4. Add a note on Triterpenoids.
5. explain the importance of steroid receptor.
6. Briefly outline the application of HPLC for the separation of plant
constituents.
7. elaborate the B-lactum agents?
8. Write a note on DNA cloning.

Earning:   Approval pending.