Tamil Nadu Dr MGR Medical University 2009 M.Pharm Drug Design and Structure and Activity Relationship - - Question Paper

MARCH -2009
[KU 327] Sub. Code: 2863
M.PHARM. DEGREE exam
(Regulations 2006)
(Candidates admitted from 2006-2007 onwards)
FIRST YEAR
Branch IV – PHARMACOLOGY
Paper IV – DRUG DESIGN AND MOLECULAR PHARMACOLOGY
Q.P. Code : 262863
Time : 3 hours Maximum : 100 marks
ans All ques.
I. Essay ques. : (3 X 20 = 60)
1. a) define different lead seeking methods in drug design.
b) Write a note on isosterism in relation to biological action and drug
design.
2. explain various approaches to the rational design of enzyme
inhibitors.
3. a) discuss signal transduction pathways for G-protein coupled
receptors.
b) elaborate ion channels? discuss how ion channels act as drug
targets.
II. Write Short Notes: (8 X five = 40)
1. Write short notes on receptor polymorphism.
2. define the clinical application of gene therapy.
3. Write about biosensors.
4. discuss about receptor dimerisation.
5 elaborate the advantages and disadvantages of natural products and lead compounds?
6. discuss about the identification of a pharmacophore in computer aided drug design.
7. How are clinical trials performed for the discovery of new drugs?
8. define the structure of G-protein coupled receptors.
*****

Earning:   Approval pending.